Hyperlipidemia / heterozygous familial hypercholesterolemia

Adult hypercholesterolaemia — 75 mg every 2 weeks or 300 mg every 4 weeks

HeFH — ≥10 years: 10–20 mg daily

Adults — start 10–20 mg daily (range 10–80)

Hypercholesterolaemia or CV risk reduction — 180 mg once daily

Hypercholesterolaemia or high CV risk — 140 mg every 2 weeks or 420 mg monthly

Hyperlipidaemia — 10 mg once daily

Primary hypercholesterolaemia or mixed dyslipidaemia — 160 mg once daily

Under 18 years

LDL lowering (≥12 y) — 284 mg, again at 3 months, then every 6 months

Hyperlipidemia — adults: 5–40 mg once daily

Heterozygous FH — 8 to <10 y: 5–10 mg

Heterozygous FH — 10–17 y: 5–20 mg

Homozygous FH — ≥7 y: 20 mg

Hyperlipidemia — adults: 20–40 mg in the evening

Heterozygous FH — ≥10 y: 10–40 mg