Rosuvastatin
رزوواستاتین
❤️ Cardiovascular SystemStatin (HMG-CoA reductase inhibitor)
Market / country: 🇺🇸 USA
Crestor (US)
🧮 Dose calculator
Hyperlipidemia / heterozygous familial hypercholesterolemia · Regimen source: FDA Rosuvastatin · 2.2
- • Asian patients: start 5 mg. Severe renal impairment (not on dialysis): start 5, max 10 mg. FDA Rosuvastatin · 2.4FDA Rosuvastatin · 2.5
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ Acute liver failure or decompensated cirrhosis; hypersensitivity. FDA Crestor · 4
Formulations
- 5 mg tablet — tablet 🇺🇸 USA FDA Crestor · 3
- 10 mg tablet — tablet 🇺🇸 USA FDA Crestor · 3
- 20 mg tablet — tablet 🇺🇸 USA FDA Crestor · 3
- 40 mg tablet — tablet 🇺🇸 USA FDA Crestor · 3
👥 Special populations
- 🤰 PregnancyDangerous / avoid
Label: can cause fetal harm. Dangerous in pregnancy. FDA Rosuvastatin · 8.1
“Rosuvastatin calcium decreases synthesis of cholesterol and possibly other biologically active substances derived from cholesterol; therefore, rosuvastatin calcium may cause fetal harm when administered to pregnant patients based on the mechanism of action [ see Clinical Pharmacology (12.1) ].”
- 🤱 BreastfeedingDangerous / avoid
Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Rosuvastatin · 8.2
“Because of the potential for serious adverse reactions in a breastfed infant, based on the mechanism of action, advise patients that breastfeeding is not recommended during treatment with rosuvastatin calcium [ see Use in Specific Populations (8.1) and Clinical Pharmacology (12.1) ].”
- 👶 ChildrenUse with caution
The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Rosuvastatin · 8.4
“The safety and effectiveness of rosuvastatin calcium as an adjunct to diet to reduce LDL-C have been established in pediatric patients 8 years of age and older with HeFH.”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Rosuvastatin · 8.5
“Dose selection for an elderly patient should be cautious, recognizing the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy and the higher risk of myopathy.”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)ANDA208898
- DailyMed (FDA label)FDA RosuvastatinFDA Crestor
- MedlinePlus (NIH)Rosuvastatin
- WHO ATC/DDDC10AA07
- Darooyab (Iran)Rosuvastatin
🇮🇷 Registered in Iran Darooyab · G-1876/Rosuvastatin
Dosage forms with Iranian generic codes, per Darooyab.
- 06454 · ROSUVASTATIN CALCIUM 10MG TAB · قرص روزوواستاتین کلسیم ۱۰ میلیگرم
- 06788 · ROSUVASTATIN CALCIUM 20MG TAB · قرص روزوواستاتین کلسیم ۲۰ میلیگرم
- 07316 · ROSUVASTATIN CALCIUM 40MG TAB · قرص روزوواستاتین کلسیم ۴۰ میلیگرم
- 07315 · ROSUVASTATIN CALCIUM 5MG TAB · قرص روزوواستاتین کلسیم ۵ میلیگرم
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Crestor · 3FDA Rosuvastatin · 2.2FDA Rosuvastatin · 2.4FDA Rosuvastatin · 2.5FDA Rosuvastatin · 2.3FDA Crestor · 4FDA Rosuvastatin · 8.1FDA Rosuvastatin · 8.2FDA Rosuvastatin · 8.4FDA Rosuvastatin · 8.5FDA Rosuvastatin · SPL approval / marketing category
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-1876/Rosuvastatin
- Clinical review⚠ Unverified