Parkinson's disease
Parkinson's disease · ICD-10: G20.A1
Symptoms
- • Tremor at rest
- • Muscle rigidity and slowness
- • Balance and walking problems, stooped posture
- • Constipation, low blood pressure on standing
- • Difficulty swallowing, infrequent blinking
Drugs and regimens
Parkinsonism — 100 mg twice daily
Parkinson "off" episodes — each dose 0.2 mL (2 mg) SC; titrate to max 0.6 mL (6 mg)
Idiopathic or postencephalitic parkinsonism (adjunct) — 1–2 mg/day (0.5–6 mg)
Parkinson’s — start one 25/100 tablet three times daily
Parkinson’s with wearing-off — 200 mg with each levodopa/carbidopa dose (max 8 times daily)
Parkinson’s (adjunct to levodopa for "off" episodes) — 50 mg once at bedtime
Parkinson’s — start 0.125 mg three times daily
Parkinson’s — monotherapy or with non-levodopa drugs: 1 mg once daily
Parkinson’s — with levodopa: 0.5 mg once daily (up to 1 mg)
Parkinson’s disease — start 0.25 mg three times daily
Early-stage Parkinson disease — start 2 mg/24 h patch; increase by 2 mg weekly to 6 mg/24 h
Advanced-stage Parkinson disease — start 4 mg/24 h; increase by 2 mg weekly to 8 mg/24 h
Parkinson’s (adjunct to levodopa) — 50 mg daily, up to 100 mg after 2 weeks
Parkinson disease with waning levodopa response — 5 mg at breakfast and 5 mg at lunch
Parkinsonism — target 6–10 mg/day divided (after titration)