Carbidopa/levodopa
کاربیدوپا-لوودوپا
🧠 Nervous SystemDopamine precursor
Market / country: 🇺🇸 USA
Sinemet (US)
🧮 Dose calculator
Parkinson's disease · Regimen source: FDA Carbidopa-levodopa · Dosage and Administration, Usual Initial Dosage
- • Add one tablet every day or every other day up to eight 25/100 tablets per day. About 70–100 mg/day carbidopa is needed to saturate decarboxylase. FDA Carbidopa-levodopa · Dosage and Administration, Usual Initial DosageFDA Carbidopa-levodopa · Dosage and Administration
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ With nonselective MAOIs; hypersensitivity; narrow-angle glaucoma. FDA Carbidopa-levodopa · Contraindications
Formulations
- 10/100 mg tablet (carbidopa/levodopa) — tablet 🇺🇸 USA FDA Carbidopa-levodopa · How Supplied
- 25/100 mg tablet (carbidopa/levodopa) — tablet 🇺🇸 USA FDA Carbidopa-levodopa · How Supplied
- 25/250 mg tablet (carbidopa/levodopa) — tablet 🇺🇸 USA FDA Carbidopa-levodopa · How Supplied
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Carbidopa-levodopa · Precautions/Warnings – Pregnancy
“No teratogenic effects were observed in a study in mice receiving up to 20 times the maximum recommended human dose of carbidopa and levodopa.”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Carbidopa-levodopa · Precautions/Warnings – Nursing Mothers
“Caution should be exercised when carbidopa and levodopa is administered to a nursing woman.”
- 👶 ChildrenSafety not established
Label: safety and effectiveness in children have not been established. FDA Carbidopa-levodopa · Precautions/Warnings – Pediatric Use
“Safety and effectiveness in pediatric patients have not been established.”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Carbidopa-levodopa · Precautions/Warnings – Geriatric Use
“In the clinical efficacy trials for carbidopa and levodopa, almost half of the patients were older than 65, but few were older than 75.”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)ANDA074260
- DailyMed (FDA label)FDA Carbidopa-levodopa
- MedlinePlus (NIH)Levodopa and Carbidopa
- WHO ATC/DDDN04BA02
- Darooyab (Iran)Levodopa-C
🇮🇷 Registered in Iran Darooyab · G-4529/Levodopa-C
Dosage forms with Iranian generic codes, per Darooyab.
- 00747 · LEVODOPA-C 110MG TAB · قرص لوودوپا–C ۱۱۰ میلیگرم
- 02383 · LEVODOPA-C 125MG TAB · قرص لوودوپا–C ۱۲۵ میلیگرم
- 06733 · LEVODOPA-C 275MG TAB · قرص لوودوپا–C ۲۷۵ میلیگرم
- 10062 · LEVODOPA-C 62.5MG TAB · قرص لوودوپا–C ۶۲٫۵ میلیگرم
- 00748 · LEVODOPA-C FORTE 250 TAB · قرص لوودوپا–C فورت ۲۵۰
- 52301 · LEVODOPA / CARBIDOPA TABLET ORAL 100 mg/25 mg · قرص لوودوپا / کاربیدوپا ۱۰۰ میلیگرم / ۲۵ میلیگرم
- 52479 · LEVODOPA / CARBIDOPA TABLET, EXTENDED RELEASE ORAL 200 mg/50 mg · قرص آهستهرهش لوودوپا / کاربیدوپا ۲۰۰ میلیگرم / ۵۰ میلیگرم
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Carbidopa-levodopa · How SuppliedFDA Carbidopa-levodopa · Dosage and Administration, Usual Initial DosageFDA Carbidopa-levodopa · Dosage and AdministrationFDA Carbidopa-levodopa · ContraindicationsFDA Carbidopa-levodopa · Precautions/Warnings – PregnancyFDA Carbidopa-levodopa · Precautions/Warnings – Nursing MothersFDA Carbidopa-levodopa · Precautions/Warnings – Pediatric UseFDA Carbidopa-levodopa · Precautions/Warnings – Geriatric UseFDA Carbidopa-levodopa · SPL approval / marketing category
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-4529/Levodopa-C
- Clinical review⚠ Unverified