Clozapine

🧮 Dose calculator

Schizophrenia · Regimen source: FDA Clozapine · 2.2FDA Clozapine · 2

• • Increase by 25–50 mg/day to target 150–225 mg twice daily; max 450 mg twice daily. Neutrophil monitoring required. FDA Clozapine · 2FDA Clozapine · 2.2

Enter age (weight is optional for this regimen).

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Clozapine · 8.1

  “Risk Summary Neonates exposed to antipsychotic drugs, including clozapine, during the third trimester are at risk for extrapyramidal and/or withdrawal symptoms following delivery ( see Clinical Considerations ).”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Clozapine · 8.2

  “Risk Summary Clozapine is present in human milk.”

• 👶 ChildrenSafety not established

  Label: safety and effectiveness in children have not been established. FDA Clozapine · 8.4

  “Safety and effectiveness in pediatric patients have not been established.”

• 👴 Older adultsDangerous / avoid

  Label: serious warning or avoid in older adults. FDA Clozapine · Boxed Warning

  “Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.”

• ⚥ Females & males of reproductive potentialNo data

  The source for this drug has no section for this group.