Tizanidine

🧮 Dose calculator

Spasticity (MS, spinal cord lesions) · Regimen source: FDA Tizanidine · 2.2

• • Increase by 2–4 mg per dose every 1–4 days; max 36 mg/day. Check liver enzymes at baseline and 1 month. Taper by 2–4 mg/day when stopping. FDA Tizanidine · 2FDA Tizanidine · 2.1FDA Tizanidine · 2.5

Enter age (weight is optional for this regimen).

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Tizanidine · 8.1

  “Risk Summary There are no adequate data on the developmental risk associated with use of tizanidine tablets in pregnant women.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Tizanidine · 8.2

  “Risk Summary There are no data on the presence of tizanidine in human milk, the effects on the breastfed infant, or the effects on human milk production.”

• 👶 ChildrenSafety not established

  Label: safety and effectiveness in children have not been established. FDA Tizanidine · 8.4

  “Safety and effectiveness in pediatric patients have not been established.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Tizanidine · 8.5

  “Monitor elderly patients because they may have an increased risk for adverse reactions associated with tizanidine tablets.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Tizanidine · 8.3

  “Oral administration of tizanidine to male and female rats resulted in adverse effects on fertility [see Nonclinical Toxicology (13.1) ].”