Fluorouracil

🧮 Dose calculator

Colorectal cancer · Regimen source: FDA Fluorouracil · 2.3

• • The calculator gives the bolus. Bolus regimen: 500 mg/m² on days 1, 8, 15, 22, 29, 36 of 8-week cycles. Test DPYD before starting. FDA Fluorouracil · 2.3FDA Fluorouracil · 2.1
• • Only under an oncologist in an equipped centre. Calculator = label mg/m² × BSA (Mosteller); protocol, cycle interval and adjustment for CBC and renal/hepatic function rest with the oncology team. FDA Fluorouracil · 2.2

Enter age and weight.

👥 Special populations

• 🤰 PregnancyDangerous / avoid

  Label: can cause fetal harm. Dangerous in pregnancy. FDA Fluorouracil · 8.1

  “Based on its mechanism of action, Fluorouracil can cause fetal harm when administered to a pregnant woman.”

• 🤱 BreastfeedingDangerous / avoid

  Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Fluorouracil · 8.3

  “Because many drugs are present in human milk and because of the potential for serious adverse reactions in nursing infants from Fluorouracil, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.”

• 👶 ChildrenSafety not established

  Label: safety and effectiveness in children have not been established. FDA Fluorouracil · 8.4

  “The safety and effectiveness in pediatric patients have not been established.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Fluorouracil · 8.5

  “Reported clinical experience has not identified differences in safety or effectiveness between the elderly and younger patients.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Fluorouracil · 8.6

  “Contraception Females Based on its mechanism of action, Fluorouracil can cause fetal harm when administered to a pregnant woman.”