Trastuzumab

🧮 Dose calculator

Breast cancer (hormonal therapy) · Regimen source: FDA Herceptin · 2.3

• • Then 6 mg/kg every 3 weeks (adjuvant up to 52 weeks). LVEF before and regularly. Not interchangeable with ado-trastuzumab emtansine or fam-trastuzumab deruxtecan. IV infusion, never bolus. FDA Herceptin · 2.3FDA Herceptin · 2.1
• • Only under an oncologist; protocol, cycle interval and adjustment rest with the treating team. FDA Herceptin · 2

Enter age and weight.

👥 Special populations

• 🤰 PregnancyDangerous / avoid

  Label: can cause fetal harm. Dangerous in pregnancy. FDA Herceptin · Boxed Warning

  “WARNING: CARDIOMYOPATHY, INFUSION REACTIONS, EMBRYO-FETAL TOXICITY, and PULMONARY TOXICITY See full prescribing information for complete boxed warning Cardiomyopathy: Herceptin can result in subclinical and clinical cardiac failure manifesting as CHF, and decreased LVEF, with greatest risk when administered …”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Herceptin · 8.2

  “Risk Summary There is no information regarding the presence of trastuzumab in human milk, the effects on the breastfed infant, or the effects on milk production.”

• 👶 ChildrenSafety not established

  Label: safety and effectiveness in children have not been established. FDA Herceptin · 8.4

  “The safety and effectiveness of Herceptin in pediatric patients have not been established.”

• 👴 Older adultsNo specific problem stated

  Label: no specific difference or dose adjustment stated for older adults. FDA Herceptin · 8.5

  “No overall differences in safety or effectiveness were observed.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Herceptin · 8.3

  “Contraception Females Herceptin can cause embryo-fetal harm when administered during pregnancy.”