Glibenclamide (glyburide)

🧮 Dose calculator

Type 2 diabetes mellitus · Regimen source: FDA Glyburide · Dosage and Administration

• • Sensitive patients: 1.25 mg. Increase by no more than 2.5 mg weekly; maintenance 1.25–20 mg/day. Above 10 mg/day twice-daily dosing may work better. FDA Glyburide · Dosage and AdministrationFDA Glyburide · Dosage and Administration, Maintenance DoseFDA Glyburide · Dosage and Administration, Dosage Interval

Enter age (weight is optional for this regimen).

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Glyburide · Pregnancy

  “Teratogenic Effects Pregnancy Category B Reproduction studies have been performed in rats and rabbits at doses up to 500 times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to glyburide.”

• 🤱 BreastfeedingDangerous / avoid

  Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Glyburide · Nursing Mothers

  “Because the potential for hypoglycemia in nursing infants may exist, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.”

• 👶 ChildrenSafety not established

  Label: safety and effectiveness in children have not been established. FDA Glyburide · Pediatric Use

  “Safety and effectiveness in pediatric patients have not been established.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Glyburide · Geriatric Use

  “Hypoglycemia may be difficult to recognize in the elderly (see PRECAUTIONS ).”

• ⚥ Females & males of reproductive potentialNo data

  The source for this drug has no section for this group.