Isoflurane
ایزوفلوران
🧠 Nervous SystemHalogenated inhalational anaesthetic
Market / country: 🇺🇸 USA
Forane (US)
🧮 Dose calculator
General anaesthesia and premedication (adjunct) · Regimen source: FDA Terrell (isoflurane) · 2.3FDA Terrell (isoflurane) · 2.4FDA Terrell (isoflurane) · 2.1
🛡️ Safety & information
Contraindications
- ⛔ Known or suspected genetic susceptibility to malignant hyperthermia; sensitivity to this or other halogenated anaesthetics; patients in whom general anaesthesia is contraindicated; prior hepatitis from a halogenated anaesthetic. FDA Terrell (isoflurane) · 4
Warnings
- • Malignant hyperthermia; perioperative hyperkalaemia (especially myopathies); QT prolongation; hepatic injury; possible neurotoxicity in children under 3 with prolonged anaesthesia. FDA Terrell (isoflurane) · 5
Formulations
- Volatile liquid for vaporizer (100%) — solution 🇺🇸 USA FDA Terrell (isoflurane) · 3
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Terrell (isoflurane) · 8.1
“Risk Summary There are no adequate and well-controlled studies in pregnant women.”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Terrell (isoflurane) · 8.2
“Due to insufficient information regarding the excretion of isoflurane in human milk, the potential risks and benefits for each specific patient should be carefully considered before isoflurane is administered to nursing women.”
- 👶 ChildrenUse with caution
The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Terrell (isoflurane) · 8.4
“During the induction of anesthesia, saliva flow and tracheobronchial secretion can increase and can be the cause of larynogospasm, particularly in children.”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Terrell (isoflurane) · 8.5
“The minimum alveolar concentration (MAC) of isoflurane decreases with increasing patient age.”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)ANDA074416
- DailyMed (FDA label)FDA Terrell (isoflurane)
- MedlinePlus (NIH)❌ None
- WHO ATC/DDDN01AB06
- Darooyab (Iran)Isoflurane
🇮🇷 Registered in Iran Darooyab · G-2670/Isoflurane
Dosage forms with Iranian generic codes, per Darooyab.
- 01943 · ISOFLURANE 100ML SOL FOR INHALATION · محلول ایزوفلوران ۱۰۰ میلیلیتر
- 01557 · ISOFLURANE 100ML SPRAY · اسپری ایزوفلوران ۱۰۰ میلیلیتر
- 53048 · ISOFLURANE INHALANT RESPIRATORY 100 % 250 mL · ایزوفلوران اینهالانت ۱۰۰ درصد ۲۵۰ میلیلیتر
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Terrell (isoflurane) · 3FDA Terrell (isoflurane) · 2.3FDA Terrell (isoflurane) · 2.4FDA Terrell (isoflurane) · 2.1FDA Terrell (isoflurane) · 4FDA Terrell (isoflurane) · 5FDA Terrell (isoflurane) · SPL approval / marketing categoryFDA Terrell (isoflurane) · 8.1FDA Terrell (isoflurane) · 8.2FDA Terrell (isoflurane) · 8.4FDA Terrell (isoflurane) · 8.5
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-2670/Isoflurane
- Clinical review⚠ Unverified