Lamotrigine

لاموتریژین

⚠ Unverified

🧠 Nervous SystemAnticonvulsant / mood stabiliser

Market / country: 🇺🇸 USA

Lamictal (US)

🧮 Dose calculator

Bipolar disorder maintenance · Regimen source: FDA Lamotrigine · 2.4FDA Lamotrigine · 2.4, Table 5

⛔ Target 200 mg/day; with valproate 100 mg/day; with carbamazepine/phenytoin/phenobarbital without valproate 400 mg/day. Escalation must follow the label tables exactly (depends on valproate or enzyme inducers) to reduce the risk of fatal rash; Doz does not calculate these tables. FDA Lamotrigine · 2.4FDA Lamotrigine · 2.4, Table 5

🛡️ Safety & information

Contraindications

  • ⛔ Hypersensitivity (rash, angioedema, urticaria, mucosal ulceration) to lamotrigine. FDA Lamotrigine · 4
  • ⚠️ Boxed warning: serious rash (SJS/TEN); 0.3–0.8% in children. Higher risk with valproate, high starting dose or rapid escalation. FDA Lamotrigine · Boxed Warning

Formulations

👥 Special populations

  • 🤰 PregnancyUse with caution

    Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Lamotrigine · 8.1

    “Risk Summary Data from several prospective pregnancy exposure registries and epidemiological studies of pregnant women have not detected an increased frequency of major congenital malformations or a consistent pattern of malformations among women exposed to lamotrigine compared with the general population (see Data ) .”
  • 🤱 BreastfeedingUse with caution

    Label: use with caution while breastfeeding; see the label text. FDA Lamotrigine · 8.2

    “Risk Summary Lamotrigine is present in milk from lactating women taking lamotrigine orally disintegrating tablets (see Data ) .”
  • 👶 ChildrenDangerous / avoid

    Boxed warning in the label about children. FDA Lamotrigine · Boxed Warning

    “The incidence of these rashes, which have included Stevens-Johnson syndrome, is approximately 0.3% to 0.8% in pediatric patients (aged 2 years to 17 years) and 0.08% to 0.3% in adults receiving lamotrigine.”
  • 👴 Older adultsUse with caution

    Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Lamotrigine · 8.5

    “In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy.”
  • ⚥ Females & males of reproductive potentialNo data

    The source for this drug has no section for this group.

📚 Reference status for this drug

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