Pregabalin

🧮 Dose calculator

Neuropathic pain (diabetic, postherpetic) · Regimen source: FDA Lyrica · 2.2FDA Pregabalin · 2

• • Within a week up to 300 mg/day (100 mg tid) if CrCl ≥60. Above 300 not recommended. FDA Lyrica · 2.2

Enter age (weight is optional for this regimen).

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Lyrica · 8.1

  “Risk Summary Observational studies on the use of Lyrica during pregnancy suggest a possible small increase in the rate of overall major birth defects, but there was no consistent or specific pattern of major birth defects identified ( see Data ).”

• 🤱 BreastfeedingDangerous / avoid

  Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Lyrica · 8.2

  “Because of the potential risk of tumorigenicity, breastfeeding is not recommended during treatment with LYRICA.”

• 👶 ChildrenUse with caution

  The label has conditions, age limits or notes for children; the label sentence is quoted below. FDA Lyrica · 8.4

  “… ents below the age of 1 month have not been established. 4 to Less Than 17 Years of Age with Partial-Onset Seizures The safety and effectiveness of LYRICA as adjunctive treatment for partial‑onset seizures in pediatric patients 4 to less than 17 years of age have been established in a 12-week, double-blind, …”

• 👴 Older adultsNo specific problem stated

  Label: no specific difference or dose adjustment stated for older adults. FDA Lyrica · 8.5

  “No overall differences in safety and efficacy were observed between these patients and younger patients.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Lyrica · 8.3

  “Infertility Males Effects on Spermatogenesis In a randomized, double-blind, placebo-controlled non-inferiority study to assess the effect of pregabalin on sperm characteristics, healthy male subjects received pregabalin at a daily dose up to 600 mg (n=111) or placebo (n=109) for 13 weeks (one complete sperm cycle) …”