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Divalproex sodium (valproate)

والپروات (دیوالپروکس)

⚠ Unverified

🧠 Nervous SystemAnticonvulsant and mood stabilizer

🤰 Pregnancy:Contraindicated🤱 Breastfeeding:Use with caution👶 Children:Dangerous / avoid👴 Older adults:Use with caution⚥ Females & males of reproductive potential:Use with caution 🇮🇷 Registered in Iran⛔ 2 contraindications 🇺🇸 FDA approved generic (ANDA) ANDA078597ATC N03AG01

Market / country: 🇺🇸 USA

Depakote (US)

🧮 Dose calculator

Epilepsy (complex partial / absence seizures) · Regimen source: FDA Divalproex · 2.2

  • • Increase 5–10 mg/kg/week; response usually below 60 mg/kg/day; serum 50–100 mcg/mL. Daily doses above 250 mg in divided doses. FDA Divalproex · 2.2

Enter age and weight.

🛡️ Safety & information

Contraindications

  • ⛔ Hepatic disease or significant dysfunction; POLG mitochondrial disorders; hypersensitivity. FDA Divalproex · 4
  • ⚠️ Under 2 years: considerably increased risk of fatal hepatotoxicity; extreme caution, sole agent. FDA Divalproex · 8.4

Warnings

Monitoring

Formulations

👥 Special populations

  • 🤰 PregnancyContraindicated

    Label: contraindicated in pregnancy. FDA Divalproex · 4

    “… ea cycle disorders [see Warnings and Precautions (5.6)] . • being treated for prophylaxis of migraine headaches who are pregnant or in women of childbearing potential who are not using effective contraception [see Warnings and Precautions (5.2, 5.3, 5.4) and Use in Specific Populations (8.1)] . • Hepatic disease or …”
  • 🤱 BreastfeedingUse with caution

    Label: use with caution while breastfeeding; see the label text. FDA Divalproex · 8.2

    “Risk Summary Valproate is excreted in human milk.”
  • 👶 ChildrenDangerous / avoid

    Boxed warning in the label about children. FDA Divalproex · Boxed Warning

    “Children under the age of two years are at a considerably increased risk of developing fatal hepatotoxicity, especially those on multiple anticonvulsants, those with congenital metabolic disorders, those with severe seizure disorders accompanied by mental retardation, and those with organic brain disease.”
  • 👴 Older adultsUse with caution

    Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Divalproex · 8.5

    “A study of elderly patients with dementia revealed drug related somnolence and discontinuation for somnolence [see Warnings and Precautions (5.16)] .”
  • ⚥ Females & males of reproductive potentialUse with caution

    Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Divalproex · 8.3

    “Contraception Women of childbearing potential should use effective contraception while taking valproate [see Boxed Warning, Warnings and Precautions (5.4), Drug Interactions (7), and Use in Specific Populations (8.1)] .”

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