Pioglitazone

🧮 Dose calculator

Type 2 diabetes mellitus · Regimen source: FDA Pioglitazone (2) · 2.1FDA Pioglitazone (2) · 2

• • NYHA I–II heart failure: start 15 mg. Increase by 15 mg up to 45. With gemfibrozil or strong CYP2C8 inhibitors max 15 mg. FDA Pioglitazone (2) · 2FDA Pioglitazone (2) · 2.3

Enter age (weight is optional for this regimen).

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Pioglitazone (2) · 8.1

  “Risk Summary Limited data with pioglitazone in pregnant women are not sufficient to determine a drug-associated risk for major birth defects or miscarriage.”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Pioglitazone (2) · 8.2

  “Risk Summary There is no information regarding the presence of pioglitazone in human milk, the effects on the breastfed infant, or the effects on milk production.”

• 👶 ChildrenSafety not established

  Label: safety and effectiveness in children have not been established. FDA Pioglitazone (2) · 8.4

  “Safety and effectiveness of pioglitazone in pediatric patients have not been established.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Pioglitazone (2) · 8.5

  “A total of 92 patients (15.2%) treated with pioglitazone in the three pooled 16- to 26-week double-blind, placebo-controlled, monotherapy trials were ≥65 years old and two patients (0.3%) were ≥75 years old.”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Pioglitazone (2) · 8.3

  “Discuss the potential for unintended pregnancy with premenopausal women as therapy with pioglitazone, like other thiazolidinediones, may result in ovulation in some anovulatory women.”