Promethazine
پرومتازین
🌬️ Respiratory SystemPhenothiazine antihistamine
Market / country: 🇺🇸 USA
Phenergan (US)
🧮 Dose calculator
Allergic conditions (hay fever, urticaria, angioedema, insect bites, chickenpox itch) · Regimen source: FDA Promethazine · Dosage and Administration
- • Or 12.5 mg before meals and at bedtime; or 6.25–12.5 mg three times daily. FDA Promethazine · Dosage and Administration
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ Boxed warning: contraindicated under 2 years (fatal respiratory depression). FDA Promethazine · ContraindicationsFDA Promethazine · Boxed Warning
- ⛔ Coma; hypersensitivity to phenothiazines; lower respiratory symptoms including asthma. FDA Promethazine · Contraindications
Formulations
- 25 mg tablet (scored) — tablet 🇺🇸 USA FDA Promethazine · How Supplied
- 6.25 mg / 5 mL syrup — syrup 🇺🇸 USA FDA Promethazine syrup · How Supplied
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Promethazine · Pregnancy Tests
“Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations.”
- 🤱 BreastfeedingDangerous / avoid
Label: breastfeeding not recommended, or choose between the drug and breastfeeding. FDA Promethazine · Nursing Mothers
“Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from promethazine hydrochloride tablets, USP a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.”
- 👶 ChildrenDangerous / avoid
Boxed warning in the label about children. FDA Promethazine · Boxed Warning
“PROMETHAZINE HYDROCHLORIDE TABLETS, USP SHOULD NOT BE USED IN PEDIATRIC PATIENTS LESS THAN 2 YEARS OF AGE BECAUSE OF THE POTENTIAL FOR FATAL RESPIRATORY DEPRESSION.”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Promethazine · Geriatric Use
“In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy.”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)ANDA040596
- DailyMed (FDA label)FDA PromethazineFDA Promethazine syrup
- MedlinePlus (NIH)Promethazine
- WHO ATC/DDDR06AD02
- Darooyab (Iran)Promethazine
🇮🇷 Registered in Iran Darooyab · G-822/Promethazine
Dosage forms with Iranian generic codes, per Darooyab.
- 10253 · PROMETHAZINE 10MG TAB · قرص پرومتازین ۱۰ میلیگرم
- 02095 · PROMETHAZINE 25MG/ML 1ML AMP · آمپول پرومتازین ۲۵ میلیگرم / میلیلیتر ۱ میلیلیتر
- 01061 · PROMETHAZINE 50MG/2ML AMP · آمپول پرومتازین ۵۰ میلیگرم / ۲ میلیلیتر
- 01060 · PROMETHAZINE 5MG/5ML 60ML SYRUP · شربت پرومتازین ۵ میلیگرم / ۵ میلیلیتر ۶۰ میلیلیتر
- 01062 · PROMETHAZINE HCL 25MG TAB · قرص پرومتازین هیدروکلراید ۲۵ میلیگرم
- 50433 · PROMETHAZINE HYDROCHLORIDE INJECTION PARENTERAL 25 mg/1mL 2 mL · فرآورده تزریقی پرومتازین هیدروکلراید ۲۵ میلیگرم / ۱ میلیلیتر ۲ میلیلیتر
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Promethazine · How SuppliedFDA Promethazine syrup · How SuppliedFDA Promethazine · Dosage and AdministrationFDA Promethazine · ContraindicationsFDA Promethazine · Boxed WarningFDA Promethazine · Pregnancy TestsFDA Promethazine · Nursing MothersFDA Promethazine · Geriatric UseFDA Promethazine · SPL approval / marketing category
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-822/Promethazine
- Clinical review⚠ Unverified