Sertraline
سرترالین
🧠 Nervous SystemSSRI
Market / country: 🇺🇸 USA
Zoloft (US)
🧮 Dose calculator
Obsessive-compulsive disorder · Regimen source: FDA Sertraline · 2.1, Table 1FDA Sertraline · 8.4
- • Increase by 25–50 mg/day weekly if needed, max 200 mg/day. FDA Sertraline · 2.1
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ Taking an MAOI (incl. linezolid or IV methylene blue) or within 14 days of stopping. FDA Sertraline · 4
- ⛔ Concomitant pimozide; hypersensitivity to sertraline. FDA Sertraline · 4
- ⚠️ In children only OCD (6–17 years) is established. FDA Sertraline · 8.4
Warnings
- • Boxed warning: increased risk of suicidal thoughts and behaviors in pediatric and young adult patients; monitor closely. FDA Sertraline · WARNING: SUICIDAL THOUGHTS AND BEHAVIORS
- • Screen for personal/family history of bipolar disorder or mania before starting. FDA Sertraline · 2.3
Formulations
- 25 mg tablet (scored) — tablet 🇺🇸 USA FDA Sertraline · 3
- 50 mg tablet (scored) — tablet 🇺🇸 USA FDA Sertraline · 3
- 100 mg tablet (scored) — tablet 🇺🇸 USA FDA Sertraline · 3
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Sertraline · 8.1
“Risk Summary Based on data from published observational studies, exposure to SSRIs, particularly in the month before delivery, has been associated with a less than 2-fold increase in the risk of postpartum hemorrhage [see Warnings and Precautions ( 5.3 ) and Clinical Considerations] .”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Sertraline · 8.2
“Risk Summary Available data from published literature demonstrate low levels of sertraline and its metabolites in human milk [See Data].”
- 👶 ChildrenDangerous / avoid
Boxed warning in the label about children. FDA Sertraline · Boxed Warning
“Antidepressants increased the risk of suicidal thoughts and behavior in pediatric and young adult patients in short-term studies.”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Sertraline · 8.5
“… significant hyponatremia in elderly patients, who may be at greater risk for this adverse reaction [See Warnings and Precautions ( 5.8 )] .”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)ANDA077670
- DailyMed (FDA label)FDA Sertraline
- MedlinePlus (NIH)Sertraline
- WHO ATC/DDDN06AB06
- Darooyab (Iran)Sertraline
🇮🇷 Registered in Iran Darooyab · G-610/Sertraline
Dosage forms with Iranian generic codes, per Darooyab.
- 05691 · SERTRALINE HCL 100MG CAP · کپسول سرترالین هیدروکلراید ۱۰۰ میلیگرم
- 01897 · SERTRALINE HCL 100MG TAB · قرص سرترالین هیدروکلراید ۱۰۰ میلیگرم
- 05934 · SERTRALINE HCL 25MG TAB · قرص سرترالین هیدروکلراید ۲۵ میلیگرم
- 05692 · SERTRALINE HCL 50MG CAP · کپسول سرترالین هیدروکلراید ۵۰ میلیگرم
- 01896 · SERTRALINE HCL 50MG TAB · قرص سرترالین هیدروکلراید ۵۰ میلیگرم
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Sertraline · 3FDA Sertraline · 2.1, Table 1FDA Sertraline · 8.4FDA Sertraline · 2.1FDA Sertraline · 4FDA Sertraline · WARNING: SUICIDAL THOUGHTS AND BEHAVIORSFDA Sertraline · 2.3FDA Sertraline · 8.1FDA Sertraline · 8.2FDA Sertraline · Boxed WarningFDA Sertraline · 8.5FDA Sertraline · SPL approval / marketing category
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-610/Sertraline
- Clinical review⚠ Unverified