Imipramine
ایمیپرامین
🧠 Nervous SystemTricyclic antidepressant
Market / country: 🇺🇸 USA
Tofranil (US)
🧮 Dose calculator
Major depressive disorder · Regimen source: FDA Imipramine · Dosage and Administration
- • Inpatients: 100 mg/day up to 200; over 200 mg/day not recommended (except resistant inpatients). Maintenance 50–150 mg/day. FDA Imipramine · Dosage and Administration
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ With MAOIs; acute recovery period after MI. FDA Imipramine · Contraindications
- ⛔ Not established under 6 years. FDA Imipramine · Pediatric Use
- ⚠️ Boxed warning: increased suicidal thoughts and behaviour in children, adolescents and young adults. FDA Imipramine · Boxed Warning
Formulations
- 10 mg tablet — tablet 🇺🇸 USA FDA Imipramine · How Supplied
- 25 mg tablet — tablet 🇺🇸 USA FDA Imipramine · How Supplied
- 50 mg tablet — tablet 🇺🇸 USA FDA Imipramine · How Supplied
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Imipramine · Pregnancy
“Animal reproduction studies have yielded inconclusive results (see also ANIMAL PHARMACOLOGY & TOXICOLOGY ).”
- 🤱 BreastfeedingUse with caution
Label: use with caution while breastfeeding; see the label text. FDA Imipramine · Nursing Mothers
“Limited data suggest that imipramine hydrochloride tablets, is likely to be excreted in human breast milk.”
- 👶 ChildrenDangerous / avoid
Boxed warning in the label about children. FDA Imipramine · Boxed Warning
“Imipramine hydrochloride is not approved for use in pediatric patients (see WARNINGS: Clinical Worsening and Suicide Risk , PRECAUTIONS, Information for Patients , and PRECAUTIONS: Pediatric Use ).”
- 👴 Older adultsUse with caution
Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Imipramine · Geriatric Use
“In general, dose selection for the elderly should be cautious, usually starting at the low end of the dosing range, reflecting greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)ANDA040903
- DailyMed (FDA label)FDA Imipramine
- MedlinePlus (NIH)Imipramine
- WHO ATC/DDDN06AA02
- Darooyab (Iran)Imipramine
🇮🇷 Registered in Iran Darooyab · G-588/Imipramine
Dosage forms with Iranian generic codes, per Darooyab.
- 00664 · IMIPRAMINE HCL 10MG TAB · قرص ایمیپرامین هیدروکلراید ۱۰ میلیگرم
- 00665 · IMIPRAMINE HCL 25MG TAB · قرص ایمیپرامین هیدروکلراید ۲۵ میلیگرم
- 00663 · IMIPRAMINE HCL 25MG/2ML AMP · آمپول ایمیپرامین هیدروکلراید ۲۵ میلیگرم / ۲ میلیلیتر
- 00666 · IMIPRAMINE HCL 50MG TAB · قرص ایمیپرامین هیدروکلراید ۵۰ میلیگرم
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Imipramine · How SuppliedFDA Imipramine · Dosage and AdministrationFDA Imipramine · ContraindicationsFDA Imipramine · Pediatric UseFDA Imipramine · Boxed WarningFDA Imipramine · PregnancyFDA Imipramine · Nursing MothersFDA Imipramine · Geriatric UseFDA Imipramine · SPL approval / marketing category
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-588/Imipramine
- Clinical review⚠ Unverified