Paroxetine

🧮 Dose calculator

Major depressive disorder · Regimen source: FDA Paroxetine · 2.2, Table 1

• • Elderly or severe renal/hepatic impairment: start 10 mg, max 40 mg. FDA Paroxetine · 2.5

Enter age (weight is optional for this regimen).

👥 Special populations

• 🤰 PregnancyUse with caution

  Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Paroxetine · 8.1

  “Risk Summary Based on data from published observational studies, exposure to SSRIs, particularly in the month before delivery, has been associated with a less than 2-fold increase in the risk of postpartum hemorrhage [see Warnings and Precautions ( 5.5 ) and Clinical Considerations].”

• 🤱 BreastfeedingUse with caution

  Label: use with caution while breastfeeding; see the label text. FDA Paroxetine · 8.2

  “Risk Summary Data from the published literature report the presence of paroxetine in human milk (see Data).”

• 👶 ChildrenDangerous / avoid

  Boxed warning in the label about children. FDA Paroxetine · Boxed Warning

  “WARNING: SUICIDAL THOUGHTS AND BEHAVIORS Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients in short-term studies.”

• 👴 Older adultsUse with caution

  Label: use with caution in older adults, usually starting at the low end of the dose range. FDA Paroxetine · 8.5

  “SSRIs including paroxetine, have been associated with cases of clinically significant hyponatremia in elderly patients, who may be at greater risk for this adverse reaction [see Warnings and Precautions ( 5.7 )].”

• ⚥ Females & males of reproductive potentialUse with caution

  Label has advice on pregnancy testing, contraception or fertility for females and males. FDA Paroxetine · 8.3

  “Infertility Male Based on findings from clinical studies, paroxetine may affect sperm quality which may impair fertility; it is not known if this effect is reversible [see Nonclinical Toxicology ( 13.1 )].”