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Perphenazine
پرفنازین
🧠 Nervous SystemPhenothiazine antipsychotic
🤰 Pregnancy:Use with caution👴 Older adults:Dangerous / avoid 🇮🇷 Registered in Iran⛔ 2 contraindications 🇺🇸 FDA approved generic (ANDA) ANDA040226ATC N05AB03
Market / country: 🇺🇸 USA
Trilafon (US)
🧮 Dose calculator
Schizophrenia · Regimen source: FDA Perphenazine · Dosage and Administration
- • Reduce to the minimum effective dose as soon as possible. Inpatients: 8–16 mg two to four times daily, max 64 mg/day. FDA Perphenazine · Dosage and Administration
Enter age (weight is optional for this regimen).
🛡️ Safety & information
Contraindications
- ⛔ Coma or greatly obtunded; large doses of CNS depressants; blood dyscrasias, marrow depression, liver damage. FDA Perphenazine · Contraindications
- ⚠️ Boxed warning: increased mortality in elderly patients with dementia-related psychosis. FDA Perphenazine · Boxed Warning
Formulations
- 2 mg tablet — tablet 🇺🇸 USA FDA Perphenazine · How Supplied
- 4 mg tablet — tablet 🇺🇸 USA FDA Perphenazine · How Supplied
- 8 mg tablet — tablet 🇺🇸 USA FDA Perphenazine · How Supplied
- 16 mg tablet — tablet 🇺🇸 USA FDA Perphenazine · How Supplied
👥 Special populations
- 🤰 PregnancyUse with caution
Label states no clear risk or has limited data; use only if needed, under medical advice. FDA Perphenazine · Pregnancy
“Perphenazine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.”
- 🤱 BreastfeedingNo data
The source for this drug has no section for this group.
- 👶 ChildrenNo data
The source for this drug has no section for this group.
- 👴 Older adultsDangerous / avoid
Label: serious warning or avoid in older adults. FDA Perphenazine · Boxed Warning
“WARNING Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.”
- ⚥ Females & males of reproductive potentialNo data
The source for this drug has no section for this group.
🔗 Reference links
- FDA (approval record)ANDA040226
- DailyMed (FDA label)FDA Perphenazine
- MedlinePlus (NIH)Perphenazine
- WHO ATC/DDDN05AB03
- Darooyab (Iran)Perphenazine
🇮🇷 Registered in Iran Darooyab · G-1325/Perphenazine
Dosage forms with Iranian generic codes, per Darooyab.
- 00972 · PERPHENAZINE 2MG TAB · قرص پرفنازین ۲ میلیگرم
- 00973 · PERPHENAZINE 4MG TAB · قرص پرفنازین ۴ میلیگرم
- 00974 · PERPHENAZINE 5MG/1ML AMP · آمپول پرفنازین ۵ میلیگرم / ۱ میلیلیتر
- 00975 · PERPHENAZINE 8MG TAB · قرص پرفنازین ۸ میلیگرم
📚 Reference status for this drug
Shows which sources have references recorded for this drug and which do not.
- FDA label (DailyMed)✅ PresentFDA Perphenazine · How SuppliedFDA Perphenazine · Dosage and AdministrationFDA Perphenazine · ContraindicationsFDA Perphenazine · Boxed WarningFDA Perphenazine · PregnancyFDA Perphenazine · SPL approval / marketing category
- UK SmPC (eMC / MHRA)❌ Not present
- Published guideline❌ Not present
- Licensed reference (medical school)❌ Not present
- Iranian leaflet (IFDA)❌ Not present
- Pharmacy website (secondary, unreliable)✅ PresentDarooyab · G-1325/Perphenazine
- Clinical review⚠ Unverified